What about a eugenic experiment aimed at radically change the character of subject populations?
My little zebra: The secrets of domestication - life - 05 October 2009 - New Scientist
He obtained 130 relatively friendly silver foxes from a fur farm in Estonia and installed them at a farm near the small town of Kainskaya Zaimka, on the outskirts of Novosibirsk. He began to breed them, but in each generation only allowed the very tamest animals to reproduce. Within four generations, some of the foxes had started to wag their tails.